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                ChemicalBook >  u瞳カタログ >  API >  森[來の >  森來弌率附|匯寳[の爺隼の工o坿 >  パクリタキセル

                パクリタキセル

                パクリタキセル 晒W夛〉塀
                33069-62-4
                • CAS桑.33069-62-4
                • 晒W兆:パクリタキセル
                • e兆:パクリタキセル;タキソ`ル;パクリタキセル (JAN)
                • 哂Z″晒W兆:Paclitaxel
                • 哂Ze兆:EMPAC;Onxal;TAXUS;TAXOL;taxal;CL183;NK 105;Capxol;Genaxol;Genexol
                • CBNumber:CB3273425
                • Molecular Formula:C47H51NO14
                • Formula Weight:853.91
                • MOL File:33069-62-4.mol
                パクリタキセル 麗尖來|
                芦畠來秤
                裡嗤墾來◇秤鵑離芥`ド(GHS)
                • }燕幣GHS
                • ]吭焼勒ZDanger
                • 裡嗤墾來秤
                • H225災諮來の互い匣wおよび對
                • H302削みzむと嗤墾
                • H312再つwに俊|すると嗤墾
                • H315再つw缶爾
                • H317坤▲譽襯`來討w郡鬉鯑陲海垢それ
                • H318砦愃Vな凛のp
                • H332採秘すると嗤墾
                • H334採秘するとアレルギ`、喚連または、柵簾是y を軟こすおそれ
                • H335査簾匂への缶爾のおそれ
                • H341在z姉埃音爾里それの夘い
                • H360塞岾嬬または魅垢悗唹のおそれ
                • H361塞岾嬬または魅垢悗唹のおそれの夘い
                • H370債匂の嬾墾
                • H371債匂の嬾墾のおそれ
                • H413咲L豚ζ議唹ω により邦伏伏麗に嗤墾のおそれ
                • ]吭き
                • P201妻荒断阿鉾Qh苧を秘返すること。
                • P210/諮雑/黛諮/互悗里發里里茲Δ返諮坿からhざ けること。鋤。
                • P260嵯曚犬//ガス/ミスト/對/スプレ`を簾秘しないこ と。
                • P261嵯曚犬//ガス/ミスト/對/スプレ`の簾秘を閲ける こと。
                • P280艮Wo返期/隠o丗/隠o凛R/隠o中を广喘するこ と。
                • P284査簾喘隠o醤を广喘すること。
                • P301+P310削みzんだ栽砦韻舛磨tにBjすること。
                • P304+P340採秘した栽鎖櫃緑濯rな侭に卞し、柵簾しやすい 徊櫃俳殤△気擦襪海函
                • P305+P351+P338済曚鉾襪辰栽宰で儀帷g]吭侮く牢うこと。肝にコ ンタクトレンズを广喘していて否叟に翌せる栽は翌す こと。その瘁も牢靴鮠Aけること。
                • P308+P313艮其または羽其の卍遒ある栽罪tの\/返てを 鞭けること。
                • P311罪tにBjすること。
                • P342+P311査簾にvするY遒竃た栽罪tにBjすること。
                • P405妻Vして隠砿すること。

                パクリタキセル MSDS


                Paclitaxel

                Paclitaxel 晒W蒙來,喘余Z,伏b圭隈

                • 翌Q 易弼゛ごくうすい砦弼、Y唱゛頚挑
                • 卑盾來 メタノ`ル卑遑犀Ym栽アセトニトリル式びメタノ`ルにやや卑けやすく、エタノ`ル(99.5)に卑けにくく、邦にほとんど卑けない。
                • 喘余 パクリタキセルは稽がん、耐zがん、皮がん、^i何がん、M佩來カポジ扉[纂宀の嵶に喘いられている。また壅M姚の嚠契にも喘いられている。 パクリタキセルは裏弌砿を芦協晒させることで裏弌砿のダイナミクスを雙崙し、そのY惚屎械な飲蛍叢のM佩を形げる。ドセタキセルと慌にta瞳主芋音瑟橋蛍のタキサンを撹する。フロリダ巒羨寄Wのロバ`ト?ホルトンによって兜めて畠栽撹された。
                • 喘余 タキソイド狼晒栽麗です。β - チュ`ブリンへY栽して裏弌砿を芦協晒さ せ、裏弌砿ダイナミクスを雙崙することによ り嗤 遼蛍叢怦墾恬喘を幣します。
                • 森來[a, 裏弌砿嶷栽怦墾a
                • 斌瞳兆 アブラキサン (寄祐逗岻瘁圭嘉己矢ia瞳垢I}); タキソ`ル (ブリストル?マイヤ`ズスクイブ)
                • h苧 Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer. Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death. The supply of paclitaxel is limited by its low natural abundance and currently it is being manufactured by a semi-synthetic route from deacetylbaccatin ‰ that is isolated from the needles of the yew tree. Recent completion of two total syntheses of taxol conquered the structural complexity of the title compound and may be useful in obtaining certain closely related analogs, some of which have been found to have antitumor activity. Paclitaxel has potential uses in the treatment of metastatic breast cancer, lung cancer, head and neck cancer, and malignant melanoma.
                • 晒W議フ慚 White Powder
                • Originator NIH (U.S.A.)
                • 聞喘 glucocorticoid, antiinflammatory
                • 聞喘 An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
                • 聞喘 Tool in study of structure and function of microtubules.
                • m鬦Y Paclitaxel (Taxol) is a highly complex, organic compound isolated from the bark of the Pacific yew tree. It binds to tubulin dimers and microtubulin filaments, promoting the assembly of filaments and preventing their depolymerization. This increase in the stability of microfilaments results in disruption of mitosis and cytotoxicity and disrupts other normal microtubular functions, such as axonal transport in nerve fibers. The major mechanism of resistance that has been identified for paclitaxel is transport out of tumor cells, which leads to decreased intracellular drug accumulation. This form of resistance is mediated by the multidrug transporter P-glycoprotein.
                • brand name Abraxane (Abraxis); Taxol (Bristol-Myers Squibb).
                • 匯違議なh苧 Needles (from aqueous methanol) or fine white powder. An anti-cancer drug.
                • 匯違議なh苧 Paclitaxel is available in single-dose vials of 30 mg/5 mLand 100 mg/16.7 mL for IV administration in the treatmentof breast, ovarian, NSCLC, and AIDS-related Kaposi sarcoma.Other uses have included treatment of head, neck,esophageal, cervical, prostate, and bladder cancers.
                  Paclitaxel is highly plasma protein bound (90%) anddoes not penetrate the CNS. Metabolism involves CYPmediatedoxidation to give 6 -hydroxypaclitaxel (CYP2C8)and para hydroxylation of the phenyl group attached to the3'-position (CYP3A4). The 6α-hydroxy metabolite normallypredominates, but the para hydroxy metabolite mayoccur to a greater degree in those patients with liver diseaseor when CYP3A4 has been induced. Both metabolites areless active than the parent and do not undergo phase II conjugationreactions. Elimination occurs primarily in the feces,and the elimination half-life is 9 to 50 hours depending onthe infusion period.
                  The major toxicity seen with paclitaxel is a dose-limitingmyelosuppression that normally presents as neutropenia. Thepreviously mentioned hypersensitivity reactions occur but aregreatly reduced by antihistamine pretreatment. Interactionwith the axonal microtubules such as that seen for the vincasalso occurs and leads to numbness and paresthesias (abnormaltouch sensations including burning and prickling). Theagent is also available as an albumin-bound formulation(Abraxane) to eliminate the need for the solubilizing agentsassociated with the hypersensitivity reactions. Other adverseeffects include bradycardia, which may progress to heartblock, alopecia, mucositis, and/or diarrhea. Paclitaxel producesmoderate nausea and vomiting that is short-lived.
                • 腎櫃繁の郡 May be sensitive to prolonged exposure to moisture. .
                • 宗慎ハザ`ド TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
                • 諮栂j Flash point data for Paclitaxel are not available. Paclitaxel is probably combustible.
                • 伏麗試來 Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
                • 恬喘C會 Paclitaxel¨s large volume of distribution indicates significant tissue binding. The drug is extensively metabolized by the liver, and doses must be reduced in patients with abnormal liver function or with extensive liver metastases.Very little of the drug is excreted in the urine.
                • R寛鮄 Paclitaxel is among the most active of all anticancer drugs, with significant efficacy against carcinomas of the breast, ovary, lung, head, and neck. It is combined with cisplatin in the therapy of ovarian and lung carcinomas and with doxorubicin in treating breast cancer.
                • 森がん冩梢 It is isolated from the bark of Taxus brevifolia generally known as pacific yew. It isprimarily used in ovarian, small, and non-small cell lung cancers and advancedbreast cancer (Shoeb 2006). It binds to tubulin but neither depolymerizes it nor interferes with its assembly (Balunas and Kinghorn 2005). Taxol targets activatorprotein 1 signaling pathways (Singh et al. 2016b).
                • 森がん冩梢 Paclitaxel (commercial name, Taxol) a complex diterpene alkaloid isnaturally obtained from Taxus species (family Taxaceae). Paclitaxel has been provedas highly effective in the treatment of various types of cancers, since it acts as amicrotubule-stabilizing agent to protect against disassembly. Paclitaxel was developed by the National Cancer Institute, USA, as a drug for cancer therapy andused for the treatment of refractory ovarian cancer, metastatic breast and lung cancer,and Kaposi¨s sarcoma (Srivastava et al. 2005). The natural source of paclitaxelis the bark of several Taxus species; however, the cost of extraction is very highsince the concentration of paclitaxel accumulation is very low (0.02% of dry weight)and also entails the destruction of natural resources (Cusido et al. 2014). Eventhough, paclitaxel can be chemically synthesized, but this process is not commerciallyviable. Plant cell cultures have been developed for the production of paclitaxelby Phyton Biotech in 1995, and in 2004 the FDA has approved the use of plantculture supply of paclitaxel/Taxol (Leone and Roberts 2013).
                • 険恬喘 Myelosuppression is the major side effect of paclitaxel. Alopecia is common, as is reversible dose-related peripheral neuropathy. Most patients have mild numbness and tingling of the fingers and toes beginning a few days after treatment. Mild muscle and joint aching also may begin 2 or 3 days after initiation of therapy. Nausea is usually mild or absent. Severe hypersensitivity reactions may occur. Cardiovascular side effects, consisting of mild hypotension and bradycardia, have been noted in up to 25% of patients.
                パクリタキセル 貧送と和送のu瞳秤
                圻可創
                簪u瞳
                パクリタキセル 伏b二I
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                33069-62-4, パクリタキセル キ`ワ`ド:
                • 33069-62-4
                • -12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4
                • 12a-alpha,12b-alpha))-12-alpha
                • 4,10-diacetate2-benzoate13-esterwith(2r,3s)-n-benzoyl-3-phenylisoserine
                • 5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one
                • -9-ylester
                • a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-y
                • benzenepropanoicacid,beta-(benzoylamino)-alpha-hydroxy-,6,12b-bis(acetyloxy)
                • bms181339-01
                • lester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alpha-r*,beta-s*),11-alph
                • nsc125973
                • nsc-125973
                • oxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydr
                • oxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet
                • peclitaxel
                • pha]]-beta-(benzoylamino)-alpha-hydroxybenzenepropanoicacid6,12b-bis(acetyl
                • Paclitaxe
                • PACLITAXEL FROM TAXUS BREVIFOLIA
                • PACLITAXEL FROM TAXUS YANNANENSIS
                • SEMI-SYMTHETIC PACLITAXEL (NON-CELL- CUL TURE)
                • PACLITAXEL, 99% NATURAL
                • PACLITAXEL, RELATED COMPOUND B10-DEACETYL-7-EPIPACLITAXEL, USP STANDARD
                • PACLITAXEL, 99.5+% NATURAL
                • PACLITAXEL, 1% PLANT EXTRACT
                • PACLITAXEL, RELATED COMPOUND ABENZENE PROPANOIC ACID, ALPHA-HYDROXY-BETA-((2-METHYL-1-OXO-2-BUTENYL)AMINO)-, 6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYLC
                • PACLITAXEL, USP STANDARD
                • PACLITAXEL, 99% SYNTHETIC
                • PACLITAXEL, 50% PLANT EXTRACT
                • Paclitaxel(Taxol)99.5%
                • Paclitaxel, 99+%
                • Benzenepropanoic acid, b-(benzoylamino)-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tet ramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
                • パクリタキセル
                • タキソ`ル
                • パクリタキセル (JAN)
                • 伏晒W
                • Y冩梢喘森[
                • ジテルペン
                • テルペン