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                L-Threonin Produkt Beschreibung

                L-Threonine Struktur
                72-19-5
                • CAS-Nr.72-19-5
                • Bezeichnung:L-Threonin
                • Englisch Name:L-Threonine
                • Synonyma:L-Threonin
                  THR;L-THR;H-THR-OH;Threonin;THREONINE;H-L-THR-OH;l-threonin;L-THREONINE;L-Threonone;L-Tlhreonine
                • CBNumber:CB5702648
                • Summenformel:C4H9NO3
                • Molgewicht:119.12
                • MOL-Datei:72-19-5.mol
                L-Threonin physikalisch-chemischer Eigenschaften
                • Schmelzpunkt: :256 °C (dec.)(lit.)
                • alpha  :-28.4 º (c=6, H2O)
                • Siedepunkt: :222.38°C (rough estimate)
                • Dichte :1.3126 (rough estimate)
                • Brechungsindex :-28 ° (C=6, H2O)
                • FEMA  :4710 | L-THREONINE
                • storage temp.  :Store at RT.
                • L?slichkeit :H2O: 50 mg/mL
                • Aggregatzustand :powder
                • pka :2.09(at 25℃)
                • Farbe :Yellow
                • PH :5-6 (100g/l, H2O, 20℃)
                • Optische Aktivit?t :[α]20/D 28.5±0.5°, c = 5% in H2O
                • Wasserl?slichkeit :90 g/L (20 ºC)
                • Merck  :14,9380
                • JECFA Number :2119
                • BRN  :1721646
                • Stabilit?t: :Stable. Incompatible with strong oxidizing agents.
                • InChIKey :AYFVYJQAPQTCCC-GBXIJSLDSA-N
                • CAS Datenbank :72-19-5(CAS DataBase Reference)
                • NIST chemische Informationen :Threonine(72-19-5)
                • EPA chemische Informationen :L-Threonine (72-19-5)
                Sicherheit
                • Kennzeichnung gef?hrlicher :Xi
                • R-S?tze: :36/37/38
                • S-S?tze: :24/25-37/39-26
                • WGK Germany  :3
                • RTECS-Nr. :XO8590000
                • Hazard Note  :Irritant
                • TSCA  :Yes
                • HS Code  :29225000

                L-Threonine Chemische Eigenschaften,Einsatz,Produktion Methoden

                • R-S?tze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
                • S-S?tze Betriebsanweisung: S24/25:Berührung mit den Augen und der Haut vermeiden.
                  S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
                  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
                • Chemische Eigenschaften A white or almost white, crystalline powder or colourless crystals.
                • Verwenden amino acid, nutrient
                • Verwenden L-enantiomer
                • Definition ChEBI: An optically active form of threonine having L-configuration.
                • Trademarks L -Threonine is JAN.
                • Biotechnologische Produktion L-Threonine can be produced using strains of E. coli or C. glutamicum. As threonine is also an amino acid of the aspartate family, aspartate semialdehyde is a common intermediate with the biosynthesis of L-lysine. In order to optimize a high-yielding L-threonine–producing strain, the following strategy is applied: the pathway towards L-lysine is minimized by reducing the activity of dihydrodipicolinate synthase (dapA) and at the same time the pathway towards L-threonine is favored by overexpression of the genes of the threonine operon, which consists of the genes for homoserine dehydratase (thrA), homoserine kinase (thrB), and threonine synthase (thrC). As L-threonine is also a precursor for L-isoleucine, further conversion of L-threonine into L-isoleucine has to be minimized by deactivation of the threonine dehydratase gene (ilvA). In the meantime, E. coli based strains have also been developed by the application of systems biology, not only by deletion or downregulation of the competing pathways such as L-lysine, L-methionine, and L-isoleucine, but also by optimization of the supply of key precursors such as oxaloacetate. The E. coli strain has been reported to produce 82 g/L L-threonine in 48 h with a carbon yield of 39 %. A more detailed description of the development of a commercial L-threonine process has been given by Debabov. Today L-threonine is manufactured on a commercial scale of several thousand tonnes using the E. coli fermentation process.
                • Sicherheitsprofil Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
                • l?uterung methode Likely impurities are allo-threonine and glycine. Crystallise L-threonine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It also crystallises from 80% EtOH to give hexagonal plates m 262-263o(dec). It sublimes at 200-226o/0.3mm with 99.6% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Elliot J Chem Soc 62 1950, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 pp 176-183, Vol 3 pp 2238-2257 1961, Beilstein 4 IV 3171.]
                L-Threonine Upstream-Materialien And Downstream Produkte
                Upstream-Materialien
                Downstream Produkte
                L-Threonin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
                Global(467)Suppliers
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                • Land:China
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                72-19-5, L-Threonine Verwandte Suche:
                • L-Threonine pharma grade
                • (2S,3R)-(-)-THREONINE
                • (2S,3R)-(-)-2-AMINO-3-HYDROXYBUTYRATE
                • (2S,3R)-2-AMINO-3-HYDROXYBUTYRIC ACID
                • 2-AMINO-3-HYDROXYBUTANOIC ACID
                • 2-AMINO-3-HYDROXYBUTYRIC ACID
                • RARECHEM AB PP 1459
                • THREONINE
                • THREONINE, L-
                • THR
                • (2S,3R)-2-Amino-3-hydroxybutyric acid~H-Thr-OH
                • L-Threonine, allo-Free
                • L-Threonine, USP Grade
                • L-THREONINE, FREE OF ALLOTHREONINE
                • L-THREONINE (USP/EP/JP)
                • L-THREONINE, 98%, 99% EE/GLC
                • L-Threonine FCC
                • L-Threonine, Feed Grade
                • L-Threonine>99%
                • L-ThreonineForBiochemistry99+%
                • L-ThreonineForBiochemistry-(2S,3R)-2-Amino-3-HydroxybutyricAcid)
                • L-ThreonineForBiochemistry
                • L-Threonine, 98+%
                • L-Threonine-UL-13C4
                • L-THREONINE,CRYSTAL
                • L-THREONINE,CRYSTAL,FCC
                • THREONINE,CRYSTAL,USP
                • THREONINE, L-(RG)
                • L-THREONINE (USP)
                • Threonine (T) Solution, 100ppm
                • L-Threonine Vetec(TM) reagent grade, >=98%
                • L-THREONINE (13C4,D5,15N)
                • L-THREONINE (4-13C,2,3-D2)
                • L-THREONINE (D5, 15N)
                • L-THREONINE UNLABELED
                • L-Threonine, Animal-Free
                • L-THREONINE BIOXTRA, >= 99.5% (NT)
                • L-THREONINE, REAGENT GRADE, >=98% (H
                • L-Threonine≥ 99.5% (Assay)
                • (s)-threonine
                • Butanoic acid, 2-amino-3-hydroxy-, [R-(R*,S*)]-
                • L-alpha-Amino-beta-hydroxybutyric acid
                • L-CH3CH(OH)CH(NH2)COOH
                • l-threonin
                • Threonin
                • L-2-AMINO-3-HYDROXYBUTANOIC ACID
                • L-2-AMINO-3-HYDROXYBUTYRIC ACID
                • L-THR
                • L(-)-THREONINE
                • L-THREONINE
                • H-L-THR-OH
                • H-THR-OH
                • H-THR-OH-THREONINE
                • L-THREONINE extrapure CHR
                • L-Tlhreonine
                • L-α-amino-β-hydroxy-butiric acid
                • L-β-hydroxy-2-aminobutyric acid
                • (2S,3R)-2-Amino-3-hydroxybutanoic acid