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                Indometacin Produkt Beschreibung

                Indometacin Struktur
                53-86-1
                • CAS-Nr.53-86-1
                • Bezeichnung:Indometacin
                • Englisch Name:Indometacin
                • Synonyma:Indometacin
                  Amuno;Vonum;Catlep;Tannex;Inacid;Lausit;INDOCIN;Bonidin;Mobilan;Dolovin
                • CBNumber:CB1750267
                • Summenformel:C19H16ClNO4
                • Molgewicht:357.79
                • MOL-Datei:53-86-1.mol
                Indometacin physikalisch-chemischer Eigenschaften
                • Schmelzpunkt: :155-162 °C
                • Dichte :1.2135 (rough estimate)
                • Brechungsindex :1.6800 (estimate)
                • storage temp.  :Store at RT
                • L?slichkeit :ethanol: 50 mg/mL, clear, yellow-green
                • Aggregatzustand :White to off-white powder
                • pka :4.5(at 25℃)
                • Wasserl?slichkeit :Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
                • Sensitive  :Light Sensitive
                • Merck  :14,4968
                • BRN  :497341
                • Stabilit?t: :Stable. Incompatible with strong oxidizing agents.
                • InChIKey :CGIGDMFJXJATDK-UHFFFAOYSA-N
                • CAS Datenbank :53-86-1(CAS DataBase Reference)
                • NIST chemische Informationen :Indomethacin(53-86-1)
                • EPA chemische Informationen :1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-(53-86-1)
                Sicherheit

                Indometacin Chemische Eigenschaften,Einsatz,Produktion Methoden

                • R-S?tze Betriebsanweisung: R28:Sehr giftig beim Verschlucken.
                  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
                • S-S?tze Betriebsanweisung: S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
                  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
                  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
                  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
                  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
                • Chemische Eigenschaften Crystalline Solid
                • Verwenden Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD
                • Verwenden antiinflammatory, antipyretic, analgesic
                • Indications Indomethacin (Indocin) is used in the treatment of acute gouty arthritis, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is not recommended for use as a simple analgesic or antipyretic because of its potential for toxicity.While indomethacin inhibits both COX-1 and COX-2, it is moderately selective for COX- 1. It produces more CNS side effects than most of the other NSAIDs. Severe headache occurs in 25 to 50% of patients; vertigo, confusion, and psychological disturbances occur with some regularity. GI symptoms also are more frequent and severe than with most other NSAIDs. Hematopoietic side effects (e.g., leukopenia, hemolytic anemia, aplastic anemia, purpura, thrombocytopenia, and agranulocytosis) also may occur. Ocular effects (blurred vision, corneal deposits) have been observed in patients receiving indomethacin, and regular ophthalmological examinations are necessary when the drug is used for long periods. Hepatitis, jaundice, pancreatitis, and hypersensitivity reactions also have been noted.
                • Definition The antiinflammatory drug indomethacin.
                • Trademarks Indocin (Merck);Argan.
                • Weltgesundheitsorganisation (WHO) Indometacin was introduced in 1963 and it is one of the first NSAIDs. Convulsions are rarely reported in relation with the use of this group of agents. Indometacin farnesil is a pro-drug of indometacin, and the occurrence of gastro-intestinal adverse effects could be expected. See also under nonsteroidal antiinflammatory agents.
                • Biologische Funktion Indomethacin (Indocin) is an acetic acid derivative related functionally to sulindac (Clinoril), a prodrug with a long half-life, and etodolac (Lodine).They are metabolized in the liver and excreted as metabolites in the bile and via the kidney. They are potent inhibitors of COX and thus extremely effective antiinflammatory agents.
                • Allgemeine Beschreibung From the time of its introduction in 1965, indomethacin(Indocin) has been widely used as an analgesic to relieve inflammatorypain associated with RA, OA and ankylosingspondylitis, and, to a lesser extent, in gout. Although both itsanalgesic and anti-inflammatory activities are well established,its use is often limited because of frequent GI distressand potential drug interactions, especially with warfarinfurosemide, and lithium (i.e., it elevates blood levels oflithium as a result of reducing renal blood flow and thereforeincreases lithium toxicities).
                  Following oral administration, indomethacin is rapidlyabsorbed and is 90% protein bound at therapeutic plasmaconcentrations. The drug has a biological half-life ofabout 5 to 10 hours and a plasma clearance of 1 to 2.5 ml/kgper minute. It is metabolized to its inactive, O-desmethyl,N-deschlorobenzoyl-, and O-desmethyl, N-deschlorobenzoylindomethacinmetabolites.
                • Allgemeine Beschreibung Crystals.
                • Air & Water Reaktionen Practically insoluble in water. Decomposes in alkali.
                • Reaktivit?t anzeigen A weak organic acid.
                • Brandgefahr Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
                • Pharmazeutische Anwendungen Indomethacin is a nonsteroidal anti-inflammatory agent used in pain and moderate to severe inflammation in rheumatic diseases and other musculoskeletal disorders. It is a COX (cyclooxygenase) inhibitor and therefore interrupts the production of prostaglandins.
                  A series of new silicon compounds, based on the structure of indomethacin, have been synthesised and are under investigation as novel anticancer agents. The carboxyl group of indomethacin was reacted with a series of amino-functionalised silanes. The resulting products have been shown to be significantly more lipophilic and more selective to COX-2. Furthermore, in vitro testing has shown an increased uptake of the new compounds at the tumour site. The silane-functionalised indomethacin derivatives exhibited a 15-fold increased antiproliferative effect when tested against pancreatic cancer .
                • Pharmazeutische Anwendungen Indomethacinis a nonsteroidal anti-inflammatory agent used in pain and moderate to severe inflammation in rheumatic diseases and other musculoskeletal disorders. It is a COX (cyclooxygenase) inhibitor and therefore interrupts the production of prostaglandins.
                • Biologische Aktivit?t Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
                • Nebenwirkungen All of these drugs produce analgesic effects, antipyresis, and antiinflammatory effects.Due to the high incidence of gastric irritation, headache, nausea, and other side effects, including hematological effects and coronary vasoconstriction, they are not useful as an initial treatment for pain. GI irritation and ulceration occur to a lesser extent with etodolac. Indomethacin is useful in the treatment of acute gout, osteoarthritis, ankylosing spondylitis, and acceleration of the closure of the ductus arteriosus in premature infants. The tocolytic effects of indomethacin to prevent preterm labor are the result of its effects on prostaglandin synthesis. However, the toxicity of the drug limits such application, since it increases fetal morbidity. Indomethacin is contraindicated in pregnancy, in asthmatics, and in those with gastric ulcers or other ulceration of the GI tract. Indomethacin may increase the symptoms associated with depression or other psychiatric disturbances and those associated with epilepsy and Parkinson’s disease. The drug should be used with caution in such patients.
                Indometacin Upstream-Materialien And Downstream Produkte
                Upstream-Materialien
                Downstream Produkte
                Indometacin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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                53-86-1, Indometacin Verwandte Suche:
                • Indomethacin - CAS 53-86-1 - Calbiochem
                • AURORA KA-6542
                • INDOCIN
                • INDOMETACIN
                • INDOMETACINE
                • INDOMETHACIN
                • INDOMETHACINE
                • LABOTEST-BB LT00244830
                • 1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
                • 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID
                • 1-(p-chlorobenzoyl)-2-methyl-5-methoxyindole-3-aceticacid
                • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylaceticacid
                • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-acetic acid
                • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-aceticaci
                • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
                • 1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico
                • 1-p-cloro-benzoil-5-metoxi-2-metilindol-3-acidoacetico
                • alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid
                • alpha-(1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)aceticacid
                • Amuno
                • Artracin
                • Artrinovo
                • Artrivia
                • Bonidin
                • Catlep
                • Chibro-amuno
                • Chrono-indicid
                • Confortid
                • Miametan
                • Mikametan
                • Mobilan
                • NCI-C56144
                • N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid
                • n-p-chlorbenzoyl-5-methoxy-2-methylindole-3-aceticacid
                • Reumacide
                • Rhemacin LA
                • Sadoreum
                • Tannex
                • Vonum
                • 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid
                • indomethacin crystalline
                • indomethacin methanol solution
                • indomethacin usp
                • INDOMETHACIN BP99
                • ndomethacin
                • N-(4-Chlorobenzoyl)-4-Methoxyphenyl-Hydrazine
                • ndometacin
                • Indomethacin,Indometacin,Amuno, Confortid, INTEBEN, Indocin
                • Indomethacin, 98%, a nonselective COX1 and COX2 inhibitor
                • INDOMETACIN TABLETS
                • 1-[P-CHLOROBENZOYL]-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
                • 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID
                • 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
                • (1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid
                • (1-p-chlorobenzoyl-5-methoxy-2-methylindol-3-yl)aceticacid
                • [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
                • 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticaci
                • 1-(4-chlorobenzoyl)-5-methoxy-2-methylindoleaceticacid